Probable clonal origin of acute myeloblastic leukemia following radiation and chemotherapy of colon cancer.

نویسندگان

  • R G Wiggans
  • R J Jacobson
  • P J Fialkow
  • P V Woolley
  • J S Macdonald
  • P S Schein
چکیده

A 64-yr-old female developed acute myeloblastic leukemia following radiation and drug therapy for colon carcinoma. The patient was heterozygous for glucose-6-phosphate dehydrogenase (G-6-PD) and displayed types A and B isoenzymes in nonhematopoietic tissue. In contrast, only type B G-6-PD was observed in peripheral blood white cells. In addition, a karyotypic abnormality was found in peripheral blood and marrow cells but not in skin fibroblasts. The data are consistent with a clonal origin of this leukemia.

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عنوان ژورنال:
  • Blood

دوره 52 4  شماره 

صفحات  -

تاریخ انتشار 1978